Correct Option: D  [ Malaria ]
Remark:
Explanation: Malaria is not caused by a virus; it is caused by a protozoan parasite of the genus Plasmodium. The disease spreads through the bite of an infected female Anopheles mosquito. The parasite enters the human bloodstream, infects liver cells, and then red blood cells, leading to recurring fever, chills, and anemia. In contrast, Smallpox, AIDS, and Flu are all viral diseases caused by the Variola virus, HIV, and Influenza virus respectively.